Strength Challenges are used to negate the effects of certain poisons. See the Poisoned condition for more information on poisons.
The potency of a poison is dictated in the form of DR challenges; Easy, Moderate, Difficult, and Extremely Difficult. The DR is at the discretion of the GM, but unless there is a circumstance that dictates it, Extremely Difficult DR challenges should be held only for Deadly Poison.